An approach to optically active ibuprofen through whole-cell and enzyme-catalyzed transformations

  • Mary Ann A. Endoma Institute of Chemistry, University of the Philippines, Quezon City
  • Maria Celeste R. Tria Institute of Chemistry, University of the Philippines, Quezon City
  • Susan D. Arco Institute of Chemistry, University of the Philippines, Quezon City
DOI: https://doi.org/10.26534/kimika.v19i2.69-75
Keywords: ibuprofen, biotransformation, enzyme-catalyzed reduction, lipase-catalyzed resolution

Abstract

Synthesis of optically active ibuprofen is attempted using two methodologies: (1) via yeast-catalyzed reduction of phenyl acrylic acid or ester 1 and derivatives 2 wherein no reduction products were detected in the biotransformation culture medium; and (2) via lipase-catalyzed resolution of racemic phenyl propanol and ibuprofen alcohol. The latter method afforded optically active ibuprofen alcohol as the (-)-S-enantiomer.
Published
2003-12-01
How to Cite
Endoma, M. A. A., Tria, M. C. R., & Arco, S. D. (2003). An approach to optically active ibuprofen through whole-cell and enzyme-catalyzed transformations. KIMIKA, 19(2), 69-75. https://doi.org/10.26534/kimika.v19i2.69-75
Issue
Vol. 19 No. 2 (2003)
Section
Research Articles

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