New Poly(Hydroxylauric-co-Lactic Acid) Liquid Polymer for Dissolving Lipophilic Drugs

  • Florentino C. Sumera Institute of Chemistry, University of the Philippines, Diliman, Quezon City 1101
  • Shienna Marie A. Pontillas Natural Sciences Research Institute, University of the Philippines, Diliman, Quezon City 1101
  • Josanelle Angela V. Bilo Natural Sciences Research Institute, University of the Philippines, Diliman, Quezon City 1101
  • John Marty Mateo Natural Sciences Research Institute, University of the Philippines, Diliman, Quezon City 1101 Institute of Plant Breeding, University of the Philippines, Los Baños, Laguna 4031
Keywords: poly(hydroxylauric acid-co-lactic acid), liquid polyester, lactic acid, hydroxy-lauric acid, polycondensation, injectables

Abstract

A liquid, biocompatible polyester based polymer, which could facilitate injectable formulations by simple mixing with the active substance (drug) is much needed by the pharmaceutical companies. A favourite candidate is polylactic acid (PLA) which is biocompatible and biodegradable. However PLA is solid with high crystallinity. Thus, in this research, hydroxylauric acid (HOLA) was copolymerized with lactic acid (LA) in different ratios by polycondensation technique at 180 °C, without a metal catalyst and avoiding the formation of interfering lactides, to provide a liquid polyester. The copolymers molecular weights were determined by Gel Permeation Chromatography (GPC) and their physical states indicated as solid or liquid were noted. The structures as polyesters were confirmed by FT-IR and 1H NMR spectroscopy. Poly(HOLA:LA)  products from reactant ratios 0:100 is solid, while ratios of 20:80, 40:60 are mixed (paste) and 60:40, 80:20 and 100:0 are liquids. Thus, the liquid polyesters from the polycondensation of HOLA and LA without catalyst  were picked as potential candidates for dissolving hydrophobic drugs that could be used as injectables in controlled drug delivery experiments.

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Published
2017-07-07
How to Cite
Sumera, F. C., Pontillas, S. M. A., Bilo, J. A. V., & Mateo, J. M. (2017). New Poly(Hydroxylauric-co-Lactic Acid) Liquid Polymer for Dissolving Lipophilic Drugs. KIMIKA, 28(1), 20-25. https://doi.org/10.26534/kimika.v28i1.20-25
Section
Research Articles