Pimaric Acid from Manila Elemi derived from Canarium Juronicum as a resolving agent in the resolution of racemic compounds

  • Susan D. R. Arco Institute of Chemistry & DA-BAR-Natural Sciences Research Institute, University of the Philippines, Diliman, Quezon City
  • Florentino C. Sumera Institute of Chemistry & DA-BAR-Natural Sciences Research Institute, University of the Philippines, Diliman, Quezon City
Keywords: Manila elemi, pimaric acid, diastereomeric salt formation, resolution of racemic compounds, (±)-α-phenyl ethylamine, (±)-ibuprofen

Abstract

Manila elemi, an oleoresin comprising mostly of resenes, resin acids and volatile oils, is one of the well-known minor forest products of the Philippines. It is an exudate of the bark of Canarium luzonicum, locally known as pili tree. It is exported mostly as raw and unprocessed resin which it has both pharmaceutical and industrial uses. In order to enhance the economic potential of Manila elemi, this study was undertaken to isolate its major chiral resin acid component, pimaric acid which is then derivatized into its amine form. Pimaric acid and pimaryl amine were evaluated for its use as potential acid and base resolving agents in the resolution of racemic α-phenyl ethylamine and racemic ibuprofen, respectively. For both compounds favorable resolutions of racemic substances were realized.
How to Cite
Arco, S. D. R., & Sumera, F. C. (1). Pimaric Acid from Manila Elemi derived from Canarium Juronicum as a resolving agent in the resolution of racemic compounds. KIMIKA, 20(1), 29-35. https://doi.org/10.26534/kimika.v20i1.29-35
Section
Research Articles