Antimutagens from Elephantopus scaber

Authors

  • Consolacion Y. Ragasa Chemistry Department, De La Salle University, Manila
  • Jennifer Sy Chemistry Department, De La Salle University, Manila
  • Virgilio Agbayani Chemistry Department, De La Salle University, Manila
  • Rowena Infante Chemistry Department, De La Salle University, Manila
  • Marc Abaya Chemistry Department, De La Salle University, Manila
  • John C. Coll University of Central Queensland, Rockhampton Campus, Queensland

DOI:

https://doi.org/10.26534/kimika.v11i1.25-28

Keywords:

Elephantopus scaber, Compositae, germacranolide, triterpene, micronucleus test, antimutagen

Abstract

The chloroform extract of the air-dried leaves of Elephantopus scaber afforded six isolates, five of which were tested for antimutagenicity potential by the Micronucleus test. The compounds were obtained by gravity column chromatography (dry packing) and their structures were elucidated by nuclear magnetic resonance spectroscopy. The isolates were identified as deoxyelephantopin, isodeoxyelephantopin, lupeol, lupeol acetate, stigmasterol and a diadinoxanthin derivative.

Results o f the antimutagenicity test showed an 81.0% reduction in micronucleated polychromatic erythrocytes (MPCE) for deoxyelephantopin; isodeoxyelephantopin, lupeol, lupeol acetate and stigmasterol likewise showed 79.3%, 80. 7%, 78.6% and 79.0% reduction in MPCE, respectively. Therefore, all compounds tested possess high antimutagenic activity.

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How to Cite

Ragasa, C. Y., Sy, J., Agbayani, V., Infante, R., Abaya, M., & Coll, J. C. (1995). Antimutagens from Elephantopus scaber. KIMIKA, 11(1), 25–28. https://doi.org/10.26534/kimika.v11i1.25-28

Issue

Vol. 11 (1995)

Section

Research Articles

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