Antimutagenic diterpenes from Andrographis paniculata

Authors

  • Zenaida D. Nacpil Chemistry Department, De La Salle University, Manila
  • Consolacion Y. Ragasa Chemistry Department, De La Salle University, Manila
  • John C. Coll Central Queensland University, Rockhampton, Queensland
  • John A. Rideout Central Queensland University, Rockhampton, Queensland

DOI:

https://doi.org/10.26534/kimika.v13i1.11-16

Keywords:

Andrographis paniculata, Acanthaceae, diterpenes, andrographolide, diacetylanhydroandrographolide, monoacetylanhydroandrographolide, deoxyanhydroandrographolide, diacetyldeoxyanhydroandrographolide, antimutagen, micronucleus test

Abstract

Andrographis paniculata afforded mixtures of diterpenes containing andrographolide (1) and deoxyanhydroandrographolide (2). The mixtures were acetylated to obtain pure compounds whose structures were elucidated by NMR spectroscopy and mass spectrometry. The structures of the natural products were deduced from the acetylated compounds. Micronucleus test of the crude extract indicated an 84.7% reduction in micronucleated polychromatic erythrocytes (MPCE); the mixture of natural productS containing 1, mixture of natural products containing 2, and acetylated compounds (3, 4, and 5) likewise exhibited 89 .8%, 86. 7%, 93.2%, 94.6% and 91.1% reduction in MPCE, respectively. Therefore, all samples tested possess high antimutagenic activity.

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How to Cite

Nacpil, Z. D., Ragasa, C. Y., Coll, J. C., & Rideout, J. A. (1997). Antimutagenic diterpenes from Andrographis paniculata. KIMIKA, 13(1), 11–16. https://doi.org/10.26534/kimika.v13i1.11-16

Issue

Vol. 13 No. 1 (1997)

Section

Research Articles

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