TY - JOUR AU - Sumera, Florentino C. AU - Pontillas, Shienna Marie A. AU - Bilo, Josanelle Angela V. AU - Mateo, John Marty PY - 2017/07/07 Y2 - 2024/03/29 TI - New Poly(Hydroxylauric-co-Lactic Acid) Liquid Polymer for Dissolving Lipophilic Drugs JF - KIMIKA JA - KIMIKA VL - 28 IS - 1 SE - Research Articles DO - 10.26534/kimika.v28i1.20-25 UR - https://kimika.pfcs.org.ph/index.php/kimika/article/view/225 SP - 20-25 AB - <p>A liquid, biocompatible polyester based polymer, which could facilitate injectable formulations by simple mixing with the active substance (drug) is much needed by the pharmaceutical companies. A favourite candidate is polylactic acid (PLA) which is biocompatible and biodegradable. However PLA is solid with high crystallinity. Thus, in this research, hydroxylauric acid (HOLA) was copolymerized with lactic acid (LA) in different ratios by polycondensation technique at 180 °C, without a metal catalyst and avoiding the formation of interfering lactides, to provide a liquid polyester. The copolymers molecular weights were determined by Gel Permeation Chromatography (GPC) and their physical states indicated as solid or liquid were noted. The structures as polyesters were confirmed by FT-IR and 1H NMR spectroscopy. Poly(HOLA:LA) &nbsp;products from reactant ratios 0:100 is solid, while ratios of 20:80, 40:60 are mixed (paste) and 60:40, 80:20 and 100:0 are liquids. Thus, the liquid polyesters from the polycondensation of HOLA and LA without catalyst &nbsp;were picked as potential candidates for dissolving hydrophobic drugs that could be used as injectables in controlled drug delivery experiments.</p> ER -