Controlled Release of Methyl Salicylate in Chitosan-Poly(N-Isoporpylacrylamide) Semi-Interpenetrating Networks

  • Terence G. Henares Department of Chemistry, School of Science and Engineering, Loyola Schools, Ateneo de Manila University, Quezon City
  • Ma. Assunta C. Cuyegkeng Department of Chemistry, School of Science and Engineering, Loyola Schools, Ateneo de Manila University, Quezon City
DOI: https://doi.org/10.26534/kimika.v23i1.26-31
Keywords: chitosan, methyl salicylate

Abstract

A semi-interpenetrating network (semi-IPN) was produced by polymerizing N-isopropylacrylamide (NIPAAm) in the presence of chitosan and cross-linking agent, ethylene glycol dimethacrylate (EGDMA). The resulting material did not swell as much as poly(N-isopropylacrylamide) (pIPAAm), but still showed temperatute- and pH- responsiveness. Swelling and differential scanning calorimetry(DSC) experiments showed that the lower critical solution temperature (LCST) of the material was at 31 C. The semi-IPN was swollen below 30 C but started to collapse at this temperature. This is in the same range as the LCST of carrageenan-pIPAAm semi-IPN. The chitosan-pIPAAm semi-IPN was in a collapsed state and reached maximum swelling at pH 9 whereas pure pIPAAm and pure chitosan both became swollen at a lower pH.

Methyl salicylate was absorbed by the semi-IPN. Its release was monitored with respect to temperature. The temperature-responsive release of methyl salicylate was more pronounced at the LCST of 31 C.

Published
2010-03-01
How to Cite
Henares, T. G., & Cuyegkeng, M. A. C. (2010). Controlled Release of Methyl Salicylate in Chitosan-Poly(N-Isoporpylacrylamide) Semi-Interpenetrating Networks. KIMIKA, 23(1), 26-31. https://doi.org/10.26534/kimika.v23i1.26-31
Issue
Vol. 23 (2010)
Section
Research Articles

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