Antimicrobial Triterpenes and Sterols from Pseuderanthemum bicolor

  • Consolacion Y. Ragasa Chemistry Department, De La Salle University, Manila
  • Josefina Yumul Chemistry Department, Adamson University, Manila
  • Jerome Ganzon Chemistry Department, Adamson University, Manila
  • John A. Rideouf School of Chemical and Biochemical Sciences, Central Queensland University, Queensland
Keywords: Pseuderanthemum bicolor, Acanthaceae, lupeol, betulin, stigmasterol, sitosterol, antimicrobial

Abstract

The dichloromethane extract of Pseuderanthemum bicolor afforded lupeol, betulin and a mixture of stigmasterol and sitosterol. Antimicrobial tests on the extract and the isolates indicated that they were active against the gram negative bacteria, Escherichia coli and Pseudomonas aeruginosa, but inactive against the gram-positive bacteria, Staphylococcus aureus and Bacillus subtilis at 30 µg. Lupeol inhibited the growth of the fungi, Candida albicans and Aspergillus niger, but did not exhibit any activity against Trichophyton mentagrophytes. The mixture of stigmasterol and sitosterol was active against C. albicans and T. mentagrophytes, but inactive against A. niger. The extract and betulin were inactive against all the fungi tested.
How to Cite
Ragasa, C. Y., Yumul, J., Ganzon, J., & Rideouf, J. A. (1). Antimicrobial Triterpenes and Sterols from Pseuderanthemum bicolor. KIMIKA, 17(1), 1-4. https://doi.org/10.26534/kimika.v17i1.1-4
Section
Research Articles