Cytotoxicity and Clastogenic Effect of Metabolite from the Marine Sponge Halisarca sp.
Keywords: marine sponge, Ha!isarca sp., cytotoxic, clastogenic
AbstractBioassay-guided fractionation of the cytotoxic butanol-soluble portion of the marine sponge Halisarca sp. afforded an aromatic Compound 1, which exhibited high cytotoxicity towards the nauplii of brine shrimp Artemia salina with an estimated acute LD50 of 323.59 ± 1.23 ppm. It revealed marginal antibacterial activity against gram-positive bacteria Stapilococcus aureus at higher concentrations of 800 and 1000 ppm. It had chromosome-breaking potential as determined using the micronucleus test at dose levels of 15 and 10 mg/kg mouse.
How to Cite
Go, J. T. O., Bajo, L. M., Uy, M. M., & Teves, F. M. (2006). Cytotoxicity and Clastogenic Effect of Metabolite from the Marine Sponge Halisarca sp. KIMIKA, 22(1), 43-46. https://doi.org/10.26534/kimika.v22i1.43-46
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