Cytotoxicity and Clastogenic Effect of Metabolite from the Marine Sponge Halisarca sp.

  • Jean Theresa O. Go Department of Chemistry, Silliman University, Dumaguete City
  • Lydia M. Bajo Department of Chemistry, Mindanao State University-Iligan Institute of Technology, Iligan City
  • Mylene M. Uy Department of Chemistry, Mindanao State University-Iligan Institute of Technology, Iligan City
  • Franco M. Teves Department of Chemistry, Mindanao State University-Iligan Institute of Technology, Iligan City
Keywords: marine sponge, Ha!isarca sp., cytotoxic, clastogenic

Abstract

Bioassay-guided fractionation of the cytotoxic butanol-soluble portion of the marine sponge Halisarca sp. afforded an aromatic Compound 1, which exhibited high cytotoxicity towards the nauplii of brine shrimp Artemia salina with an estimated acute LD50 of 323.59 ± 1.23 ppm. It revealed marginal antibacterial activity against gram-positive bacteria Stapilococcus aureus at higher concentrations of 800 and 1000 ppm. It had chromosome-breaking potential as determined using the micronucleus test at dose levels of 15 and 10 mg/kg mouse.
Published
2006-04-01
How to Cite
Go, J. T. O., Bajo, L. M., Uy, M. M., & Teves, F. M. (2006). Cytotoxicity and Clastogenic Effect of Metabolite from the Marine Sponge Halisarca sp. KIMIKA, 22(1), 43-46. https://doi.org/10.26534/kimika.v22i1.43-46
Section
Research Articles