Novel Chitosan Microparticles for Sequestration of Overdosed Drug
Chitosan microparticles were synthesized by crosslinking chitosan and glycidyl trimethylammonium chloride modified chitosan inside the reverse micelles of Span and Tween 80. The particles were of uniform size with the average diameter of 10 μm. The particles swelled almost twice the original size in 20 min when dispersed in a buffer solution of pH 7.4. The feasibility of chitosan microparticles as drug sequestrant was tested using propafenone as the model drug. The particles sequestered free propafenone from a buffer solution of pH 7.4. In 20 min unmodified chitosan and modified chitosan microparticles sequestered 53% and 51.5% of the free drug respectively. The amount of drug sequestered increased with increase in the initial free drug concentration. The presence of normal saline also improved propafenone sequestration.
Bae JW, Lee JH, Choi WS, Lee DS, Bae EH, Park KD. EPDIM peptide-immobilized porous chitosan beads for enhanced wound healing: Preparation, characterizations and in vitro evaluation. Mater Sci Eng C. 2009; 29(3):697-701.
Bano I, Arshad M, Yasin T, Afzal Ghauri M, Younus M. Chitosan: A potential biopolymer for wound management. Int J Biol Macromolec. 2017; 102: 380–383.
Bernkop-Schnürch A, Dünnhaupt S. Chitosan-based drug delivery systems. Eur J Pharm Biopharm. 2012; 81(3): 463-469.
Bhardwaj N, Nguyenqt, Chen AC, Kaplan DL, Sah RL. Potential of 3-D tissue constructs engineered from bovine chondrocytes/silk fibroin-chitosan for in vitro cartilage tissue engineering. Biomaterials. 2011; 32: 5773-5781.
Chakraborty S, Somasunadaran P. Sequestration of drugs using poly(acrylic acid) and alkyl modified poly(acrylic acid) nanoparticles. Soft Matter. 2006; 2:850-854.
Dhanikula A, Khalid N, Lee S, Yeung R, Risovic V, Wasan K, Leroux J. Long circulating lipid nanocapsules for drug detoxification. Biomaterials. 2007; 28: 1248-1257.
Dini J, Alexandridou S, Kiparissides C. Synthesis and characterization of cross-linked chitosan microspheres for drug delivery applications. J Microencapsulation. 2003; 20(3): 375–385.
Hu Y, Ding Y, Ding D, Sun M, Zhang L, Jiang X, Yang C. Hollow Chitosan/Poly(acrylic acid) Nanospheres as Drug Carriers. Biomacromolecules. 2007; 8:1069-1076.
Hua W, Ying W, Xiaoying C, Quan W. Proliferation of chondrocytes on porous poly(dl-lactide)/ chitosan scaffolds. Acta Biomaterialia. 2008; 4(1):76-87.
Kim JK, Lee JK, Lee TS, Park WH. Synthesis of chitooligosaccharide derivative with quaternary ammonium group and its antimicrobial activity against Streptococcus mutants. Int J Biol Macromol. 2003; 32: 23–27.
Kong M, Zuo Y, Wang M, Bai X, Feng C, Chen X. Simply constructed chitosan nanocarriers with precise spatiotemporal control for efficient intracellular drug delivery. Carbohyd Polym. 2017; 169(1): 341–350.
Li J, Shi B, Yan S, Jin L, Guo Y. Li T, Guo X. Effects of dietary supplementation of chitosan on humoral and cellular immune function in weaned piglets. Anim Feed Sci Technol. 2013; 204-208.
Liu H, Fan H, Cui Y, Chen Y, Yao K, Goh JCH. Effects of the Controlled-Released Basic Fibroblast Growth Factor from Chitosan-Gelatin Microspheres on Human Fibroblasts Cultured on a Chitosan-Gelatin Scaffold. Biomacromolecules. 2007; 8:1446-1455.
Morey T, Varshney M, Flint J. Rajasekaran S, Shah D, Dennis D. Treatment of Local Anesthetic-Induced Cardiotoxicity Using Drug Scavenging Nanoparticles. Nano Letters. 2004; 4(4): 757-759.
Muzzarelli RAA. Chitosan-based dietary foods. Carbohyd Polym. 1996; 29(4): 309-316.
Papadimitriou S, Bikiaris D, Avgoustakis K, Karavas E, Georgarakis, M. Chitosan nanoparticles loaded with dorzolamide and pramipexole. Carbohydr Polym. 2008; 73: 44-54.
Sinha VR, Singla AK, Wadhawan S, Kaushik R, Kumria R, Bansal K, Dhawan S. Chitosan microspheres as a potential carrier for drugs. Int J Pharm. 2004; 274(1-2): 1-33.
Sivashankari PR, Prabaharan M. Prospects of chitosan-based scaffolds for growth factor release in tissue engineering. Int J Biol Macromolec. Part B, 2016; 93:1382-1389.
Tian Y, Sun Y, Wang X, Kasparis G, Mao S. Chitosan and its derivatives-based nano-formulations in drug delivery. Nanobiomaterials in Drug Delivery, 2016; 9: 515-572.
Wu Y, Yang W, Wang C, Hu J, Fu S. Chitosan nanoparticles as a novel delivery system for ammonium glycyrrhizinate, Int J Pharm. 2005; 295: 235–245.
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