A Sesquiterpene from Dysidea sp. and Its DNA-Binding Profile

Authors

  • Alexander O. Mosqueda Department of Chemical Engineering Technology, Mindanao State University-Iligan Institute of Technology, Iligan City
  • Roberto M. Malaluan Department of Chemical Engineering Technology, Mindanao State University-Iligan Institute of Technology, Iligan City
  • Lydia M. Bajo Department of Chemical Engineering Technology, Mindanao State University-Iligan Institute of Technology, Iligan City
  • Franco G. Teves Department of Chemical Engineering Technology, Mindanao State University-Iligan Institute of Technology, Iligan City
  • Ivan van Altena Department of Chemistry, School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW
  • Mihiko Yanai Natural Science Center for Basic Research and Development, Hiroshima University, Higashi-Hiroshima

DOI:

https://doi.org/10.26534/kimika.v23i1.38-42

Keywords:

Dysidea, NMR, sesquiterpene, arenarol, antimicrobial, DNA-binding

Abstract

The sesquiterpene arenarol (1) was isolated from the marine sponge, Dysidea sp. by supercritical fluid extraction and reversed-phase high performance liquid chromatography. The molecular structure was elucidated on the basis of 1H and 13C-NMR chemical shifts. The isolated secondary metabolite exhibited a very week antimitcrobial activity at 15 ug against Staphylococcus aures, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa, and showed a DNA-binding property with a retention factor ratio of 0.76 by one dimensional thin-layer chromatography.

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Published

2010-03-01

How to Cite

Mosqueda, A. O., Malaluan, R. M., Bajo, L. M., Teves, F. G., van Altena, I., & Yanai, M. (2010). A Sesquiterpene from Dysidea sp. and Its DNA-Binding Profile. KIMIKA, 23(1), 38–42. https://doi.org/10.26534/kimika.v23i1.38-42

Issue

Vol. 23 (2010)

Section

Research Articles

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