Quantitative Structure-Activity Relationship Study of Curcumin Analogues as Anti-proliferative Agents of Human Prostate Cancer Cell Line (PC-3)

Authors

  • Andrea Marie M. Reyes Department of Physical Sciences and Mathematics, College of Arts and Sciences, University of the Philippines Manila, Manila
  • Junie B. Billones Department of Physical Sciences and Mathematics, College of Arts and Sciences, University of the Philippines Manila, Manila

DOI:

https://doi.org/10.26534/kimika.v24i1.8-17

Keywords:

curcumin, PC-3 prostate cancer, quantitative structure-activity relationship study

Abstract

A quantitative structure-activity relationship (QSAR) study has been performed on curcumin analogues in order to establish the effect of variation of structural, electronic and topological properties  on  the  anti-proliferative  activity  against  prostate  cancer  cell  line  PC-3.  The structure-based  properties  were  calculated  by  the  use  of  Hyperchem®  and  Dragon® softwares  and  the  multi-linear  regression  equations  were  generated  by  the  use  of  SPSS® software. Six models of PC-3 activity have been developed according to the types of QSAR descriptors.  All  models  were  cross-validated  using  leave-one-out  (LOO)  method.  The models  indicate  that  a  more  potent  curcumin  derivative  against  PC-3  should  have  smaller surface area, greater volume, lower polarizability, and fewer oxygen and multiple bonds.

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Published

2013-01-21

How to Cite

Reyes, A. M. M., & Billones, J. B. (2013). Quantitative Structure-Activity Relationship Study of Curcumin Analogues as Anti-proliferative Agents of Human Prostate Cancer Cell Line (PC-3). KIMIKA, 24(1), 8–17. https://doi.org/10.26534/kimika.v24i1.8-17

Issue

Vol. 24 No. 1 (2013)

Section

Research Articles

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