Lipophilic halogen-free ionic liquid with antibacterial and anti-biofilm activities against Pseudomonas aeruginosa

  • Kris Corinne D. C. Laserna Chemistry Department, De La Salle University, 2401 Taft Avenue, 0922 Manila
  • Christian Deo T. Deguit Chemistry Department, De La Salle University, 2401 Taft Avenue, 0922 Manila
  • Wilfred F. Ong Chemistry Department, De La Salle University, 2401 Taft Avenue, 0922 Manila
  • Drexel H. Camacho Chemistry Department, De La Salle University, 2401 Taft Avenue, 0922 Manila and Organic Materials and Interfaces Unit, CENSER, De La Salle University, 2401 Taft, Avenue, Manila
Keywords: ionic liquid, imidazolium stearate, halogen-free ionic liquid, antimicrobial, anti-biofilm, lipophilic

Abstract

A halogen-free ionic liquid (IL) designed with long alkyl chain anion is reported. 1-methylimidazolium stearate (MIM stearate) synthesized through Bronsted acid-base reaction has shown improved lipophilic character and is able to penetrate bacterial cell walls. Antimicrobial activities against Gram-negative bacteria, Escherichia coli, and Pseudomonas aeruginosa were observed. Anti-biofilm assays showed effectivity against the biofilm of Pseudomonas aeruginosa. At 50 µg/mL the %biofilm inhibition of MIM stearate towards P. aeruginosa biofilm formation is comparable to the Bromofuran positive control. Brine shrimp lethality assay showed weak toxicity indicating the IL to be safe and benign. The synthesized MIM stearate showed good promise as an antimicrobial and anti-biofilm agent.

Published
2018-12-28
Section
Research Articles